Guideline Detail

Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach—second edition 2016

Source: World Health Organisation
Publication Date: June 1, 2016

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2016 updated guideline from the World Health Organisation. Topics include: HIV diagnosis, including retesting prior to enrolment in care; pre- and post-testing services; principles of and approaches to service delivery; HIV diagnosis in infants and children; HIV diagnosis in other priority populations; diagnostics. Clinical guidelines on antiretroviral drugs for HIV prevention, including, oral pre-exposure prophylaxis for preventing the acquisition of HIV; postexposure prophylaxis and combination HIV prevention. Clinical guidelines on antiretroviral therapy including preparing people living with HIV for ART; what to expect in the first months of ART; when to start ART; first-line ART; monitoring the response to ART and diagnosing treatment failure; monitoring of and substitutions for ARV drug toxicities; key ARV drug interactions; second- and third-line ART. Clinical guidelines on managing coinfections and comorbidities, including prevention, screening and management of common coinfections; prevention, screening and management of other comorbidities and chronic care for people living with HIV. Service delivery, including differentiated care; models of community ARV delivery; linkage from HIV testing to enrolment in care; retention in care; adherence; frequency of clinic visits and medication pickup; task shifting and task sharing; decentralization; integrating and linking services; delivering HIV services to adolescents; improving the quality of HIV care services; procurement and supply management systems for HIV health products; laboratory and diagnostic services. Monitoring and evaluation, including selection of indicators; data collection and disaggregation; reviewing and strengthening monitoring and evaluation, systems.evaluation, including impact and programme performance; other key monitoring considerations. Appendices include: WHO clinical staging of HIV disease in adults, adolescents and children; doses of recommended antiretroviral drugs; viral load testing strategy; key drug interactions for antiretrovirals; algorithm for the management of people with HIV and suspected of having TB; algorithm for the management of people with HIV and suspected of having TB (seriously ill patients); periodic evaluation of TB infection control in health facilities; checklists for decision-making and implementation; models and country case studies of phased implementation of policies.

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Keywords: HIV - Resource-Limited Settings, HIV - First-line Therapy, HIV - Adverse Events, HIV - Tuberculosis, HIV - Acute HIV Infection, HIV - Monitoring, HIV - Special Populations, HIV - Pregnancy, HIV - Viral Hepatitis Coinfection