Guideline Detail

Post-Exposure Prophylaxis

Source: Southern African HIV Clinicians Society
Publication Date: November 1, 2008

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2008 guidelines aimed at specifically addressing the use of postexposure prophylaxis in South Africa. Topics covered include: scale of occupational and nonoccupational injury; core principles for postexposure prophylaxis; prevention of HIV exposure in the workplace; special occupational exposure situations; postsexual exposure, including outside of a relationship where disclosure about the exposure is not desired and children; selecting patients for antiretroviral interventions; selecting antiretroviral regimens for postexposure prophylaxis; justification for 3 instead of 2 drugs and for alternatives to zidovudine; routine baseline and follow-up investigations; investigating the exposed person, including HIV testing, hepatitis B and C virus testing, and testing for other blood-borne pathogens; monitoring for adverse drug reactions; comorbidities; counselling issues, including anxiety management; and risk-taking interventions.

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Keywords: HIV - Adverse Events, HIV - Monitoring, HIV - Paediatric/Adolescent Patients, HIV - Pregnancy, HIV - Prevention, HIV - Psychosocial Issues, HIV - Renal Complications, HIV - Special Populations, HIV - Resource-Limited Settings, HIV - Women