Guideline Detail

Antiretroviral Therapy for HIV Infection in Infants and Children: Towards Universal Access—Recommendations for a Public Health Approach

Source: World Health Organisation
Publication Date: January 1, 2010

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2010 recommendations from the World Health Organisation based on a public health approach to HIV care and harmonised with treatment guidelines for adults, pregnant women, and for the prevention of mother- to- child transmission. Topics addressed include: establishing a diagnosis of HIV infection in infants and children; when to start antiretroviral therapy (ART) in infants and children; recommended first-line ART regimens for infants and children; clinical and laboratory monitoring; what to expect in the first 6 months of ART; antiretroviral drug toxicity; substituting drugs because of toxicity in infants and children; first-line treatment failure; when to switch regimens; choice of second-line regimens; considerations for infants and children with tuberculosis and HIV; nutrition for HIV-infected infants and children; considerations for ART in adolescents; adherence to ART; strategies in the event of second-line regimen failure; and drug resistance.

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Keywords: HIV - Adherence, HIV - Adverse Events, HIV - Diagnosis, HIV - First-line Therapy, HIV - Monitoring, HIV - Paediatric/Adolescent Patients, HIV - Drug Resistance, HIV - Resource-Limited Settings, HIV - Special Populations, HIV - Switch Strategies, HIV - Treatment-Experienced Patients, HIV - Tuberculosis, Tuberculosis - Paediatrics