Guideline Detail

Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infections in Infants

Source: World Health Organisation
Publication Date: January 1, 2010

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2010 recommendations from the World Health Organisation aimed at updating recommendations for the use of antiretroviral agents in pregnant women for their own health and to prevent HIV infection in infants and young children and at simplifying and standardising current recommendations to support the global scale-up of more effective interventions to eliminate mother-to-child HIV transmission (MTCT) in resource-limited settings. Topics addressed include: antiretroviral drugs for treating pregnant women for their own health and to prevent HIV infection in their infants, including antiretroviral therapy (ART) eligibility for pregnant women, ART regimens for pregnant women eligible for treatment, ART regimens for women of childbearing age receiving treatment for their own health, antiretroviral prophylaxis for infants born to women receiving ART, and clinical and laboratory monitoring of pregnant women receiving ART for their own health and their infants; maternal and infant antiretroviral prophylaxis to prevent MTCT for HIV-infected women who do not need treatment for their own health, including antiretroviral prophylaxis for women and their infants to reduce perinatal HIV transmission, maternal zidovudine plus antiretroviral prophylaxis to prevent MTCT, maternal triple antiretroviral prophylaxis to prevent MTCT, women diagnosed during labour or immediately postpartum, and clinical and laboratory monitoring of pregnant women receiving antiretroviral prophylaxis and their infants; special considerations, including antiretroviral regimens for women previously exposed to antiretroviral drugs, women who acquire primary infection during pregnancy or breast-feeding, women with anaemia, women with HIV-2 infection, women with active tuberculosis, women with hepatitis B or hepatitis C virus coinfection, and pregnant women living with HIV who are injecting drug users; safety and risk of resistance to antiretroviral drugs in pregnant women and their infants; and health systems considerations of antiretroviral-based interventions for women and infants.

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Keywords: HIV - Acute HIV Infection, HIV - First-line Therapy, HIV - IV Drug Use, HIV - Monitoring, HIV - Pregnancy, HIV - Drug Resistance, HIV - Resource-Limited Settings, HIV - Treatment-Experienced Patients, HIV - Tuberculosis, HIV - Viral Hepatitis Coinfection, HIV - Women, HIV - Paediatric/Adolescent Patients, HIV - Prevention