Guideline Detail

Rapid Advice: Diagnosis, Prevention and Management of Cryptococcal Disease in HIV-Infected Adults, Adolescents and Children

Source: World Health Organisation
Publication Date: December 1, 2011

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2011 World Health Organisation rapid advice on managing cryptococcal disease in HIV-infected patients with a focus on 6 key areas: diagnosis of cryptococcal disease; screening and prevention of cryptococcal disease; induction, consolidation, and maintenance antifungal treatments; prevention, monitoring, and management of drug toxicities; timing of antiretroviral therapy (ART) initiation; and timing of discontinuation of fluconazole maintenance treatment (secondary prophylaxis). The objectives of the document are to provide a summary of key evidence and its assessment and to provide recommendations on the prevention, diagnosis, and management of cryptococcal disease in HIV-infected adults, adolescents, and children, with an emphasis on resource-limited settings with a high burden of cryptococcal disease; to outline standards for high-quality care of persons living with HIV and patients with cryptococcal disease; to identify gaps and prioritize areas in need of further clinical and operational research.

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Keywords: HIV - Resource-Limited Settings, HIV - Cryptococcus