Guideline Detail

Xpert MTB/RIF assay for the diagnosis of pulmonary and extrapulmonary TB in adults and children

Source: World Health Organisation
Publication Date: January 1, 2013

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2013 World Health Organisation policy statement on the use of real-time nucleic acid amplification technology (Xpert MTB/RIF)  for detecting tuberculosis and rifampicin resistance. Topics include using Xpert MTB/RIF to diagnose pulmonary TB and rifampicin resistance in adults (as a replacement test for smear microscopy; as an add-on test following microscopy; using Xpert MTB/RIFto detect smear-positive culture-positive; to detect smear-negative culture-positive; to detect pulmonary TB in HIV-negative and HIV- positive individuals; to detect rifampicin resistance); using Xpert MTB/RIF to diagnose extrapulmonary TB and rifampicin resistance in adults and children (Detecting lymph node TB in samples from biopsy or fine-needle aspiration; detecting pleural TB in pleural fluid;  detecting TB in samples of CSF; detecting TB in gastric fluid; detecting TB in tissue samples; detecting rifampicin resistance; using Xpert MTB/RIF to diagnose TB and rifampicin resistance in children; affordability and cost effectiveness of using Xpert MTB/RIF to diagnose TB; WHO policy recommendations on using Xpert MTB/RIFto diagnose pulmonary and extrapulmonay TB and rifampicin resistance in adults and children.

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Keywords: Tuberculosis - Tests and Assays